About PS
Phosphatidylserine is a phospholipid concentrated in brain cell membranes. RCTs show it can blunt cortisol response to physical and mental stress at 400–800 mg/day. Also studied for cognitive function in older adults. Well tolerated with no serious adverse effects reported. No established RDA/UL.
What PS supports
- May blunt cortisol response to stress
- Supports cognitive function, especially under stress
How much PS to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
300–800
mg
400 mg minimum effective dose in cortisol-blunting RCTs; 300 mg allows partial credit on dose curve.
Clinical evidence
Moderate clinical evidence. Several clinical trials show cortisol-blunting effects at 400-800mg/day under stress conditions
Examine.com