About SPMs
Omega-3-derived signaling lipids (resolvins, protectins, maresins and their precursors like 18-HEPE/17-HDHA), sold as concentrated marine-oil fractions. Mechanistic work on inflammation resolution is substantial, but clinical supplement evidence is early and limited. Doses are far below therapeutic omega-3 ranges, so this is scored separately from fish oil.
What SPMs supports
- May support inflammation resolution — mechanistically plausible but human evidence is early, no confirmatory RCTs
Clinical evidence
Limited clinical evidence. Strong mechanistic basis but only early, small human studies; clinical efficacy unproven.
NIH Fact Sheet