About Thymosin Beta-4 Fragment
A synthetic fragment of thymosin beta-4, a naturally occurring protein involved in cell migration, wound healing, and angiogenesis. Animal injection studies show tissue repair and anti-inflammatory effects. Zero human RCTs for oral supplementation. TB-500 is banned by WADA as a prohibited growth factor. The intact peptide is a 43-amino acid chain almost certainly degraded by GI proteases before absorption. Regulatory status is gray-area — sold as a 'research chemical.'
What Thymosin Beta-4 Fragment supports
- Animal injection data for tissue repair — zero human RCTs for oral use
- WADA-banned; oral bioavailability almost certainly negligible
How much Thymosin Beta-4 Fragment to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
2–10
mg
Supplement doses range 2–10 mg/day. No human RCTs establish a therapeutic oral dose. Animal studies use injection. Oral bioavailability is uncharacterized.
Clinical evidence
Limited clinical evidence. Zero human RCTs — all data from animal injection studies. 43-amino acid peptide almost certainly degraded orally. WADA-banned substance.
NIH Fact Sheet