About Yohimbe
An African bark (Pausinystalia johimbe) and its alkaloid yohimbine, an alpha-2 antagonist marketed for erectile function and fat loss. Yohimbine has some RCT support for ED, but crude yohimbe supplements have wildly variable and often mislabeled alkaloid content and can cause hypertension, anxiety and arrhythmia. ⚠️ FDA has issued public-health warnings; hypertensive crises have occurred at doses as low as 5 mg, especially with blood-pressure medication. Contraindicated with MAOIs, stimulants, antidepressants and cardiovascular drugs; restricted or banned in several countries.
What Yohimbe supports
- Alpha-2 antagonist marketed for ED and fat loss
How much Yohimbe to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
5–20
mg
Refers to yohimbine content; ED/fat-loss studies used ~5-20 mg yohimbine/day. Crude bark has unpredictable alkaloid content.
Clinical evidence
Limited clinical evidence. Yohimbine has ED evidence; crude bark is variable and carries CV risks
Examine.com