About Zembrin
Standardized Sceletium tortuosum extract with dual PDE4 inhibitor and 5-HT reuptake inhibitor activity. A 2023 meta-analysis of 4 studies (117 participants) found no clinical difference vs placebo for anxiety. One acute RCT (25 mg) showed mixed results. Mechanism is well-characterized but clinical evidence for stress/anxiety is minimal.
What Zembrin supports
- Dual PDE4 + serotonin reuptake mechanism
- May reduce acute pre-stress anxiety (1 small RCT, mixed)
How much Zembrin to take
Clinical studies typically use 8–25 mg of Zembrin. RCTs used 8–25 mg/day. Safety trial used both doses; acute behavioral study used 25 mg single dose.
- Effective range
- 8–25 mg
Clinical evidence
Limited clinical evidence. Meta-analysis of 4 studies (117 participants) found no clinical difference vs placebo for anxiety
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