About PepZin GI
Zinc-L-carnosine (polaprezinc) is a chelated compound of zinc and L-carnosine that adheres to the gastric lining, delivering both zinc and carnosine directly to the stomach wall. Originally developed in Japan as a prescription gastroprotective agent. Clinical studies show it supports gastric mucosal integrity, helps with H. pylori-related damage, and may reduce gut permeability ('leaky gut'). Distinct from regular zinc supplements — the chelate structure allows targeted delivery to the GI tract. Generally well tolerated. No established RDA/UL for the chelate.
What PepZin GI supports
- Supports gastric mucosal lining integrity and stomach comfort
- May help protect the gut lining from NSAID and stress-related damage
- Studied for reducing gut permeability (leaky gut)
- Used as a prescription gastroprotective agent in Japan since 1994
How much PepZin GI to take
Clinical studies typically use 37.5–75 mg of PepZin GI. Standard dose is 75 mg/day of zinc-L-carnosine complex (providing ~16 mg elemental zinc and ~59 mg L-carnosine), typically split into two 37.5 mg doses. PepZin GI by Hamari Chemicals is the most clinically studied branded form.
- Effective range
- 37.5–75 mg
Clinical evidence
Moderate clinical evidence. Several clinical studies as a Japanese prescription gastroprotective; targeted gut delivery mechanism
NIH Fact Sheet