About PepZin GI
Zinc-L-carnosine (polaprezinc) is a chelated compound of zinc and L-carnosine that adheres to the gastric lining, delivering both zinc and carnosine directly to the stomach wall. Originally developed in Japan as a prescription gastroprotective agent. Clinical studies show it supports gastric mucosal integrity, helps with H. pylori-related damage, and may reduce gut permeability ('leaky gut'). Distinct from regular zinc supplements — the chelate structure allows targeted delivery to the GI tract. Generally well tolerated. No established RDA/UL for the chelate.
What PepZin GI supports
- Supports gastric mucosal lining integrity and stomach comfort
- May help protect the gut lining from NSAID and stress-related damage
- Studied for reducing gut permeability (leaky gut)
- Used as a prescription gastroprotective agent in Japan since 1994
How much PepZin GI to take
The RDA prevents deficiency. The effective range is what clinical trials used to actually move the outcome.
Effective
37.5–75
mg
Standard dose is 75 mg/day of zinc-L-carnosine complex (providing ~16 mg elemental zinc and ~59 mg L-carnosine), typically split into two 37.5 mg doses. PepZin GI by Hamari Chemicals is the most clinically studied branded form.
Clinical evidence
Moderate clinical evidence. Several clinical studies as a Japanese prescription gastroprotective; targeted gut delivery mechanism
NIH Fact Sheet