BioStacks
37 / 100Poor
Best for
Score Breakdown
Formulation
62
Safety
59
Final score
37/100
Ingredients (2)
Niacinamide
100%Dose
500 mg
Target
25–500 mg
Form
Standard
Calcium
80%Dose
160 mg
Target
200–600 mg
Form
Budget
Other Ingredients (10)
TalcAnti-caking
IARC classifies cosmetic-grade talc not containing asbestos as Group 2B (possibly carcinogenic to humans); perineal talc use as Group 2A (probably carcinogenic). Johnson & Johnson voluntarily withdrew talc-based baby powder from US/Canada in 2020 and globally in 2022 after extensive litigation tied to ovarian-cancer and mesothelioma cases. The 2018 FDA contamination survey found asbestos in 9 of 52 cosmetic talc products tested. As a supplement excipient talc is a pure manufacturing convenience — no nutritional or functional benefit to the user — so the asbestos-exposure risk has no offsetting upside. Safer alternatives (silicon dioxide, microcrystalline cellulose, rice hulls) are widely available.
Polysorbate 80Emulsifier
Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Polyethylene Glycol (Coating)Coating
A polyether polymer used as a tablet coating and plasticizer
Polyvinyl AlcoholCoating
Synthetic, water-soluble polymer used as a film former and binder in immediate-release tablet coatings
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Gum AcaciaBinder
Natural plant gum (acacia) used as a binder, stabilizer, and emulsifier in foods and supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.