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Centrum

AgeDefy for Women 35+

2 Tablets · 30 servings

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What it does

A combination of 26 label ingredients.

Vitamin A

Mixed formsGrade —

Supports normal vision, immune function and the maintenance of healthy tissues.

Vitamin B7

Form not confirmedGrade —

Supports normal fat and amino-acid metabolism; hair-growth benefits without deficiency have not been established.

DentalImmuneGeneral Health
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Ingredients (28)

IngredientDoseTarget/referenceForm

Other ingredients

Titanium DioxideColorant

Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.

Polysorbate 80Emulsifier

Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.

TalcAnti-caking

IARC classifies cosmetic-grade talc not containing asbestos as Group 2B (possibly carcinogenic to humans); perineal talc use as Group 2A (probably carcinogenic). Johnson & Johnson voluntarily withdrew talc-based baby powder from US/Canada in 2020 and globally in 2022 after extensive litigation tied to ovarian-cancer and mesothelioma cases. The 2018 FDA contamination survey found asbestos in 9 of 52 cosmetic talc products tested. As a supplement excipient talc is a pure manufacturing convenience — no nutritional or functional benefit to the user — so the asbestos-exposure risk has no offsetting upside. Safer alternatives (silicon dioxide, microcrystalline cellulose, rice hulls) are widely available.

Titanium DioxideColorant

Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.

CarmineColorant

Insect-derived (not vegan/vegetarian) and a recognized cause of IgE-mediated allergic reactions, including documented anaphylaxis. The FDA mandated explicit 'carmine'/'cochineal extract' labeling in 2011 specifically because of these reactions. Not toxic to the general population, but a genuine allergen with no health benefit; plant pigments achieve the same color.

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Polyethylene Glycol (Coating)Coating

A polyether polymer used as a tablet coating and plasticizer

Polyvinyl AlcoholCoating

Synthetic, water-soluble polymer used as a film former and binder in immediate-release tablet coatings

Lab testing

How to take it

With a meal containing fat
Keep it away from coffee, tea and dairy
Space it a couple of hours from Green Tea Leaf Extract

On the label

Take 2 tablets daily.

Price check

$19.96

$0.67 / serving

$10$20$50

Cheaper than 65% of 798 multivitamins

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Daily Vits

NOW

Daily Vits

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57

Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

Not medical advice. Consult your healthcare professional.

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