This **Serrapeptase** capsule delivers 40,000 SPU, landing right at the low end of the range used in clinical trials for reducing post-surgical swelling and easing sinus congestion. Most studies dose around 60,000 SPU daily, so one capsule covers the minimum — you'd take two to sit mid-range.

It comes enteric-coated, which matters: this enzyme is destroyed by stomach acid without that protection, so the coating plus the label's empty-stomach instruction are what let it actually reach your system.

The evidence is genuine but limited. A handful of mostly small, older RCTs point to reduced edema and thinner mucus, so treat the benefits as plausible rather than established — and skip it if you're on blood thinners, since the label flags that interaction.

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Doctor's Best

Serrapeptase 40,000 SPU

1 Capsule · 90 servings

iHerbAmazon

Ingredients (2)

Serrapeptase

100%

Dose

40000 SPU

Target

40000–120000 spu

Form

—

Calcium

27 mg

Trace amount — not scored

Other Ingredients (4)

Coating (unspecified)Coating

Generic tablet coating declaration where the label does not itemize the coating's components; modern aqueous film coatings are typically cellulose-based (HPMC) with a plasticizer

Gellan GumGelling Agent

Microbial polysaccharide produced by Sphingomonas elodea, used as a gelling and stabilizing agent

HypromelloseCapsule

Plant-derived capsule material from cellulose

Purified WaterSolvent

Water meeting USP specifications used as solvent/vehicle in gummies and liquids

How to Take It

Take it anytime

Timing doesn't matter for this one — taking it consistently does.

With or without food

On the label

Suggested Adult Use: Take 1 capsule daily with at least 8 oz. of water on an empty stomach, or as recommended by a nutritionally informed physician.

General guidance based on the ingredients, not a substitute for the label or your doctor.

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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