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GNC

Calcium 600 + Vitamin D-3

1 Caplet · 225 servings

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What it does

A combination of 2 label ingredients.

Calcium

calcium carbonateBudget

Label lists Calcium (600 mg). Benefit information is limited.

Vitamin D

cholecalciferolPremium

Label lists Vitamin D (10 mcg). Benefit information is limited.

DentalBone & Joint
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Ingredients (2)

IngredientDoseTarget/referenceForm

Other ingredients

Polysorbate 80Emulsifier

Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.

Titanium DioxideColorant

Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.

FD&C Yellow No. 6Colorant

May trigger sensitivity in some individuals; behavioral concerns in susceptible children

MaltodextrinBinder

Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.

SucroseSweetener

Added sugars and high glycemic load; dental caries risk

Medium Chain Triglyceride OilCarrier

Fractionated oils rich in C8/C10 triglycerides used as neutral carrier or anti-sticking agent

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Polyethylene Glycol (Coating)Coating

A polyether polymer used as a tablet coating and plasticizer

Lab testing

How to take it

With a meal containing fat
Keep it away from high-oxalate foods like spinach
Space it a couple of hours from Iron, Magnesium and Zinc

On the label

Take 1 caplet daily.

Price check

$9.99

$0.04 / serving

$10$20$50

Cheaper than 85% of 294 calcium supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

Not medical advice. Consult your healthcare professional.

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