BioStacks
Best for
Ingredients (2)
Vitamin D
40%Dose
400 IU
Target
1000–5000 IU
Form
Premium
Calcium
100%Dose
600 mg
Target
200–600 mg
Form
Budget
Other Ingredients (17)
Polysorbate 80Emulsifier
Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.
Titanium DioxideColorant
Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.
FD&C Yellow No. 6Colorant
May trigger sensitivity in some individuals; behavioral concerns in susceptible children
MaltodextrinBinder
Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.
SucroseSweetener
Added sugars and high glycemic load; dental caries risk
Medium Chain Triglyceride OilCarrier
Fractionated oils rich in C8/C10 triglycerides used as neutral carrier or anti-sticking agent
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Polyethylene Glycol (Coating)Coating
A polyether polymer used as a tablet coating and plasticizer
How to Take It
Take it anytime
Fat-soluble — take with your largest fat-containing meal. Time of day doesn't matter.
With a meal containing fat
Keep it away from high-oxalate foods like spinach
Space it a couple of hours from Iron, Magnesium and Zinc
On the label
Take 1 caplet daily.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$9.99
Cheaper than 88% of 638 calcium supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.