BioStacks
GNC

Vitamin B-12 Timed-Release 1000 mcg

1 Caplet · 90 servings · $0.17/serving

iHerbAmazon

Best for

Dental

Ingredients (2)

Vitamin B12

100%

Dose

1000 mcg

Target

250–5000 mcg

Form

Budget

Calcium

100%

Dose

220 mg

Target

200–600 mg

Form

Not listed

Other Ingredients (16)

Polysorbate 80Emulsifier

Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.

Rice FlourFiller

Rice-based ingredients carry risk of inorganic arsenic contamination (FDA and Consumer Reports). Rice accumulates arsenic from soil at higher rates than other grains. Used as a cheap filler — adds nothing beneficial.

Rice FlourFiller

Rice-based ingredients carry risk of inorganic arsenic contamination (FDA and Consumer Reports). Rice accumulates arsenic from soil at higher rates than other grains. Used as a cheap filler — adds nothing beneficial.

ShellacCoating

Natural resin secreted by the lac bug, used as a coating and glazing agent for tablets and pills

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Polyethylene Glycol (Coating)Coating

A polyether polymer used as a tablet coating and plasticizer

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

MonoglyceridesEmulsifier

Glycerol monoesters of fatty acids used as emulsifiers and processing lubricants

How to Take It

Best taken in the morning

The Vitamin B12 in it is what pulls this toward the morning. Calcium is easier on the stomach taken with food.

With food
Keep it away from high-oxalate foods like spinach
Space it a couple of hours from Iron, Magnesium and Zinc

On the label

As a dietary supplement, take one caplet daily.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$14.99

$10$20$50

Cheaper than 72% of 660 calcium supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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