Your body needs folate for DNA synthesis, cell division, and healthy methylation — and this delivers it in the most usable form. **Methylfolate** ((6S)-5-MTHF, Quatrefolic) at 680mcg DFE bypasses the multi-step conversion that synthetic folic acid requires, which matters especially if you have MTHFR gene variants that slow that conversion.

The 680mcg DFE dose (equivalent to 400mcg of methylfolate) sits right in the clinical range of 400–800mcg. It covers the RDA of 400mcg and gives you meaningful support for energy metabolism and prenatal health. The Quatrefolic branded form is one of the most bioavailable methylfolate sources available.

If you're looking for higher-dose folate support — for example during pregnancy planning, where 800mcg+ is often recommended — you'd need to double up on capsules or choose a higher-strength product. For general daily folate needs, this dose is well-matched.

BioStacks
Jarrow Formulas

Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules

1 Capsule · 60 servings · $0.17/serving

iHerbAmazon

Ingredients (1)

Folate as (6S)-5-MTHF

100%

Dose

680 mcg

Target

400–800 mcg

Form

Premium

Other Ingredients (2)

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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