Your body needs folate for DNA synthesis, cell division, and healthy methylation — and this delivers it in the most usable form. **Methylfolate** ((6S)-5-MTHF, Quatrefolic) at 680mcg DFE bypasses the multi-step conversion that synthetic folic acid requires, which matters especially if you have MTHFR gene variants that slow that conversion.

The 680mcg DFE dose (equivalent to 400mcg of methylfolate) sits right in the clinical range of 400–800mcg. It covers the RDA of 400mcg and gives you meaningful support for energy metabolism and prenatal health. The Quatrefolic branded form is one of the most bioavailable methylfolate sources available.

If you're looking for higher-dose folate support — for example during pregnancy planning, where 800mcg+ is often recommended — you'd need to double up on capsules or choose a higher-strength product. For general daily folate needs, this dose is well-matched.

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BioStacks

Jarrow Formulas

Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules

Capsule · 60 servings · $0.17/serving

97 / 100Excellent

Score Breakdown

Formulation
97
Safety
100
Final score
97/100

Ingredients (1)

Folate as (6S)-5-MTHF680 mcg

Optimal dose · Premium form

Label Nutrition Facts

Active Ingredients

From the label · % Daily Value

DV%

Folate as (6S)-5-MTHF680 mcg

170%

Other Ingredients

Fillers, coatings, and additives

2Safe

Magnesium StearateLubricant

Safe

Microcrystalline CelluloseBinder

Safe

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.