This is a high-dose active folate for people who don't convert ordinary folic acid well. The label says 8500 mcg DFE, but methylfolate counts as roughly 1.7x its real weight in DFE units — so you're actually getting about 5,000 mcg of **L-methylfolate** per tablet. That's still many times the 400 mcg daily requirement, well into therapeutic territory for methylation, mood, and red blood cell formation.

Because this is B9 in its already-active form, it works without the multi-step MTHFR conversion that synthetic folic acid requires. That matters because roughly 40-50% of people carry MTHFR variants that blunt that conversion — for them, this skips the bottleneck.

A dose this high is meant for a real job — correcting deficiency or practitioner-directed methylation and mood protocols — not routine daily coverage, where far less would do.

BioStacks
Life Extension

High Potency Optimized Folate 8500 mcg DFE

1 Tablet · 30 servings · $0.45/serving

iHerbAmazon

Ingredients (1)

Folate

100%

Dose

8500 mcg dfe

Target

400–800 mcg

Form

Premium

Other Ingredients (6)

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

Vegetable StearateLubricant

A plant-derived salt of stearic acid (typically magnesium or calcium) used as a tablet lubricant

Croscarmellose SodiumDisintegrant

Cross-linked cellulose derivative used as a superdisintegrant

Dicalcium PhosphateBinder

Calcium and phosphorus compound used as binder

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Stearic AcidLubricant

Saturated fatty acid used as tablet lubricant

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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