BioStacks
Best for
Ingredients (2)
5-HTP
100%Dose
100 mg
Target
100–300 mg
Form
—
Calcium
70 mgTrace amount — not scored
Other Ingredients
No other ingredients listed
How to Take It
Best taken in the evening
Take in the evening. Amino acids compete for the same transport into the brain, so a protein-heavy meal blunts it.
On an empty stomach
Keep it away from protein-heavy meals
Space it a couple of hours from SAMe
On the label
1 caplet 2-3 times daily with meals or as directed by a health professional. To minimize the risk of gastrointestinal side effects, slowly increase dose over a period of 2 weeks.
Labels usually say “with food” because it's gentler on the stomach, not because it absorbs better. Fasted absorbs more — start there, and switch to a light meal if it bothers you.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$34.96
Pricier than 70% of 54 5-HTP supplements
Track this supplement in your stack
Get personalized insights, interactions, and coverage recommendations.
Get Started FreeSimilar Supplements
Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.