If you're looking for natural mood and stress support, this product uses **affron**, a patented saffron extract standardized to 3.5% lepticrosalides. You're getting 28mg per serving — just under the 30mg dose used in most clinical trials, but close enough that you're likely in the effective range. Meta-analyses show saffron extract at this dose can meaningfully reduce symptoms of low mood and anxiety.

The affron brand specifically has its own clinical trials behind it, which gives you more confidence that the extract quality matches what was actually studied. Saffron works through serotonin-related pathways, and most studies show effects within 4–8 weeks of daily use.

At 28mg versus the standard 30mg research dose, you're getting about 93% of the studied amount — a minor shortfall. Keep in mind that saffron supplements are not a substitute for professional mental health care if your symptoms are severe.

BioStacks
Natural Factors Stress-Relax

100% Pure Saffron Extract

2 Capsules · 30 servings · $0.70/serving

iHerbAmazon

Best for

Stress & Mood

Ingredients (1)

Affron

100%

Dose

28 mg

Target

14–30 mg

Form

—

Other Ingredients (6)

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Stearic AcidLubricant

Saturated fatty acid used as tablet lubricant

Purified WaterSolvent

Water meeting USP specifications used as solvent/vehicle in gummies and liquids

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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