Pro Quench (Tropical Orange Mango)

Dose context matters. As a trace excipient in a tablet coating or capsule, the amount is minimal and not a meaningful concern. The evidence below applies to the gram-level intakes typical of sweetened protein powders, pre-workouts, and drink mixes: a 2022 human trial (Suez et al., Cell) showed sucralose disrupts gut bacteria and worsens blood sugar control in healthy adults, and a 2023 study (Schiffman et al.) found that sucralose-6-acetate — a compound formed when sucralose is digested — was genotoxic to human cells in vitro. It remains an artificial sweetener with no nutritional purpose.

May trigger hyperactivity in sensitive children; potential link to allergic reactions

Older NTP rodent studies (1980s, contested) reported lymphoma and leukemia at very high chronic doses; modern reviews (FDA 2003, EFSA 2000) concluded no cancer risk at human exposure levels but the issue is not fully resolved (Mishra 2020 review). Animal evidence suggests gut microbiome disruption (Bian 2017 — male mice on Ace-K showed altered microbiota and metabolic markers). Manufacturing uses methylene chloride, with potential residue concerns. Purely cosmetic additive — risk:benefit unfavorable for supplements.

Artificial azo dye; ADI-limited; associations with hyperactivity in sensitive children in some studies.

Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.

Vitamin C used as an antioxidant preservative in supplements to prevent oxidation

Natural acid derived from citrus fruits

Sodium salt of citric acid used for pH control, tartness, and chelation in gummies