Interaction checker
Can you take St. John's Wort with SAMe?
St. John's Wort + SAMe — Serotonin Riskhigh
Both enhance serotonin signaling through different mechanisms. Combining serotonergic supplements raises the risk of serotonin syndrome. Do not combine without medical supervision.
Supplement-to-supplement only. For interactions with prescription medications, talk to your doctor or pharmacist.
Add more to your stack
St. John's WortSAMe
St. John's Wort + SAMe — Serotonin Riskhigh
Both enhance serotonin signaling through different mechanisms. Combining serotonergic supplements raises the risk of serotonin syndrome. Do not combine without medical supervision.
Do St. John's Wort and SAMe actually work at your doses?
BioStacks scores supplements on clinical efficacy — real doses vs. the research. Scan a bottle and see.