Interaction checker
Can you take St. John's Wort with Tryptophan?
St. John's Wort + Tryptophan — Serotonin Riskhigh
Tryptophan is converted to serotonin via 5-HTP. Combining it with St. John's Wort (a serotonin reuptake inhibitor) raises the risk of serotonin syndrome. Do not combine without medical supervision.
Supplement-to-supplement only. For interactions with prescription medications, talk to your doctor or pharmacist.
Add more to your stack
St. John's WortTryptophan
St. John's Wort + Tryptophan — Serotonin Riskhigh
Tryptophan is converted to serotonin via 5-HTP. Combining it with St. John's Wort (a serotonin reuptake inhibitor) raises the risk of serotonin syndrome. Do not combine without medical supervision.
Do St. John's Wort and Tryptophan actually work at your doses?
BioStacks scores supplements on clinical efficacy — real doses vs. the research. Scan a bottle and see.