BioStacks

Best MSM for Skin

Top 5 products ranked

Last reviewed May 2026

Clinical dose: 1000–3000 mg

Why MSM for Skin

MSM plays a supporting role in skin. MSM is an organic sulfur compound found naturally in foods. Sulfur is essential for the formation of connective tissue, including cartilage, tendons, and ligaments. In clinical studies, msm sulfur supports keratin production for hair, skin, and nail health.

What dose to look for

Clinical studies typically use 1000–3000 mg of msm. Most studies use 1000–3000 mg/day. OptiMSM is the most clinically studied branded form, purified via distillation. Doses up to 6000 mg/day have been used in clinical trials without significant adverse effects. Products below this range may not deliver meaningful results.

What the research says

MSM has moderate clinical evidence for skin benefits. Several clinical trials on joint comfort and inflammation, but most are small to moderate in size Learn more

Clinical research on MSM (Methylsulfonylmethane)

LOW-MODERATE — limited but promising · 1,000–3,000 mg/day

•Provides bioavailable sulfur needed for keratin and collagen cross-linking
•Small studies suggest benefits for skin elasticity and nail strength, but evidence is limited

See full Skin research →