About Citrulline
L-Citrulline is a non-essential amino acid that converts to L-arginine in the kidneys, raising plasma arginine and nitric oxide levels more effectively than oral arginine supplementation (arginine undergoes significant first-pass metabolism). Well-tolerated with no established UL. Citrulline malate is the most common supplemental form.
What Citrulline supports
- Raises nitric oxide more effectively than oral arginine
- May reduce exercise-induced fatigue and improve endurance
- Supports healthy blood flow and blood pressure
How much Citrulline to take
Clinical studies typically use 3000–6000 mg of Citrulline. 3-6g/day for NO-mediated blood flow and exercise performance. Citrulline malate studies often use 6-8g (which contains ~3-4.5g pure citrulline).
- Effective range
- 3000–6000 mg
Clinical evidence
Moderate clinical evidence. Several trials show it raises nitric oxide more effectively than oral arginine for blood flow
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