BioStacks
21st Century

One Daily Men's Health

1 Tablet · 100 servings

iHerbAmazon
31 / 100Poor

Best for

DentalImmuneBone & Joint

Score Breakdown

Formulation
48
Safety
54
Final score
31/100

Ingredients (22)

Vitamin D3

100%

Dose

1000 IU

Target

1000–5000 IU

Form

Premium

Iodine

100%

Dose

150 mcg

Target

150–500 mcg

Form

Premium

Vitamin B6

100%

Dose

2.2 mg

Target

1.3–25 mg

Form

Premium

Pantothenic Acid

31%

Dose

15.5 mg

Target

50–500 mg

Form

Premium

Niacin

70%

Dose

17.6 mg

Target

25–500 mg

Form

Standard

Other Ingredients (13)

TalcAnti-caking

IARC classifies cosmetic-grade talc not containing asbestos as Group 2B (possibly carcinogenic to humans); perineal talc use as Group 2A (probably carcinogenic). Johnson & Johnson voluntarily withdrew talc-based baby powder from US/Canada in 2020 and globally in 2022 after extensive litigation tied to ovarian-cancer and mesothelioma cases. The 2018 FDA contamination survey found asbestos in 9 of 52 cosmetic talc products tested. As a supplement excipient talc is a pure manufacturing convenience — no nutritional or functional benefit to the user — so the asbestos-exposure risk has no offsetting upside. Safer alternatives (silicon dioxide, microcrystalline cellulose, rice hulls) are widely available.

Polysorbate 80Emulsifier

Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Polyethylene Glycol (Coating)Coating

A polyether polymer used as a tablet coating and plasticizer

Polyvinyl AlcoholCoating

Synthetic, water-soluble polymer used as a film former and binder in immediate-release tablet coatings

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Croscarmellose SodiumDisintegrant

Cross-linked cellulose derivative used as a superdisintegrant

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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