BioStacks
Best for
Ingredients (11)
L-Leucine
100%Dose
3600 mg
Target
2000–5000 mg
Form
—
Potassium
100%Dose
110 mg
Target
99–500 mg
Form
—
L-Isoleucine
100%Dose
1800 mg
Target
1500–4000 mg
Form
—
L-Valine
100%Dose
1800 mg
Target
1500–4000 mg
Form
—
L-Methionine
100%Dose
250 mg
Target
200–1000 mg
Form
—
Other Ingredients (8)
SucraloseSweetener
Dose context matters. As a trace excipient in a tablet coating or capsule, the amount is minimal and not a meaningful concern. The evidence below applies to the gram-level intakes typical of sweetened protein powders, pre-workouts, and drink mixes: a 2022 human trial (Suez et al., Cell) showed sucralose disrupts gut bacteria and worsens blood sugar control in healthy adults, and a 2023 study (Schiffman et al.) found that sucralose-6-acetate — a compound formed when sucralose is digested — was genotoxic to human cells in vitro. It remains an artificial sweetener with no nutritional purpose.
Acesulfame PotassiumSweetener
Older NTP rodent studies (1980s, contested) reported lymphoma and leukemia at very high chronic doses; modern reviews (FDA 2003, EFSA 2000) concluded no cancer risk at human exposure levels but the issue is not fully resolved (Mishra 2020 review). Animal evidence suggests gut microbiome disruption (Bian 2017 — male mice on Ace-K showed altered microbiota and metabolic markers). Manufacturing uses methylene chloride, with potential residue concerns. Purely cosmetic additive — risk:benefit unfavorable for supplements.
Artificial FlavorsFlavor
Composition is proprietary and not disclosed on the label, so allergens or solvents cannot be verified. Naturally flavored alternatives are more transparent.
MaltodextrinBinder
Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.
Natural FlavorsFlavor
Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Citric AcidAcidulant
Natural acid derived from citrus fruits
PotassiumMineral
Essential mineral naturally present in many plant-based supplement ingredients
How to Take It
Best taken in the evening
Contains Tryptophan, so it belongs in the evening. Take it with food — the potassium in it is what makes this kind of product feel nauseating on an empty stomach.
With food
Keep it away from protein-heavy meals
Space it a couple of hours from SAMe
On the label
Take 1 serving (1 scoop) Mix in 8oz of Water. Pre, Intra or Post Exercise.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$34.99
Pricier than 71% of 28 leucine supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.