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GNC

Calcium Citrate 1000 mg

Other · 2 Caplets × 2/day · 90 servings

iHerbAmazon

Best for

DentalBone & Joint

Ingredients (1)

Calcium

100%

Dose/day

2000 mg

Target

200–600 mg

Form

Premium

Other Ingredients (10)

Polysorbate 80Emulsifier

Chassaing et al. 2015 (Nature, PMID 25731162) tested polysorbate 80 directly and showed it thinned the gut mucus barrier, altered microbiota composition, and induced low-grade inflammation and metabolic syndrome in mice. The strongest human evidence is for a related emulsifier rather than polysorbate 80 itself: Chassaing 2022 (Gastroenterology, PMID 34774538) was a controlled human feeding RCT of carboxymethylcellulose (CMC) that found microbial encroachment into the mucus layer — polysorbate 80 has not been tested in an equivalent human trial. In vitro work (e.g. Roberts 2010) shows polysorbate 80 enhances bacterial translocation across intestinal epithelium, and observational data link overall dietary-emulsifier exposure to IBD risk. EFSA is mid re-evaluation of polysorbates (E432–E436). For a supplement excipient with purely cosmetic function (improving the look/texture of soft gels and liquids), the gut-barrier risk profile is unfavorable when safer alternatives (sunflower lecithin, MCT carriers, gum acacia) are widely available.

Magnesium StearateLubricant

A salt of stearic acid used as a lubricant in tablet and capsule production

Polyethylene Glycol (Coating)Coating

A polyether polymer used as a tablet coating and plasticizer

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

MonoglyceridesEmulsifier

Glycerol monoesters of fatty acids used as emulsifiers and processing lubricants

Carnauba WaxCoating

Hard plant wax from the carnauba palm used to glaze gummies and tablets

Croscarmellose SodiumDisintegrant

Cross-linked cellulose derivative used as a superdisintegrant

HypromelloseCapsule

Plant-derived capsule material from cellulose

How to Take It

Take it anytime

Take with food and split doses above 500 mg — absorption drops at higher single doses.

With food
Keep it away from high-oxalate foods like spinach
Space it a couple of hours from Iron, Magnesium and Zinc
Split into 2 doses across the day

On the label

Directions: As a dietary supplement, take two caplets at breakfast and two caplets at dinner for a total of four caplets daily.

General guidance based on the ingredients, not a substitute for the label or your doctor.

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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