Creatine Gummies (Sour Peach)

Witkowski et al. 2023 (Nature Medicine, PMID 36849732) reported elevated plasma erythritol associated with major adverse cardiovascular events (MACE) in two cohorts (n=4,000+), with in-vitro and ex-vivo evidence of enhanced platelet aggregation. Replication is ongoing; FDA and EFSA have not changed their safety positions, but the signal is real and the additive is purely cosmetic. Better-established concern: GI tolerance — single doses above ~50 g cause osmotic diarrhea. Lower threshold for children.

A poorly-absorbed sugar alcohol that can cause bloating, gas, and laxative effects at higher doses (EFSA notes laxative threshold for polyols). Tolerable for most, but cumulative across products.

Worst GI tolerance of the common sugar alcohols — laxative effect at doses above ~10–15 g/serving in many adults; threshold is lower in children. Glycemic index (~52) is significantly higher than erythritol (0) or xylitol (~7) — meaningful blood glucose impact at typical serving sizes. The 'sugar-free' marketing claim masks real metabolic effects when consumed in quantity.

Beta-carotene used in small amounts as a colorant/antioxidant.

Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.

Natural red colorant and mild flavoring derived from beetroot; often spray-dried onto maltodextrin carrier

Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements

Natural acid derived from citrus fruits