This methyl folate spray delivers a full daily dose of **folate** (B9) in its bioactive 5-MTHF form — one spray gives you 680 mcg DFE (from 400 mcg of L-methylfolate), within the 400–800 mcg effective range for DNA synthesis, cell division, and methylation. Folate matters most before and during pregnancy, where adequate intake is the best-established way to lower neural tube defect risk.

The form is what makes this work for you. Around 40–50% of people carry an MTHFR variant that makes converting synthetic folic acid into usable folate harder; the 5-MTHF here skips that step, so you absorb it regardless of your genetics — and one spray covers the full dose, no pills.

For pregnancy, 400 mcg meets the standard prevention dose, though some providers suggest more when you're actively trying to conceive. Otherwise this covers daily folate needs simply and completely.

BioStacks
NB Pure

Methyl Folate Spray

Liquid · 1 Spray (0.172 ml) · 175 servings · $0.10/serving

iHerbAmazon

Ingredients (1)

Folate

100%

Dose

680 mcg DFE

Target

400–800 mcg

Form

Premium

Other Ingredients (2)

GlycerinHumectant

Sweet-tasting liquid used in soft capsules and liquids

Purified WaterSolvent

Water meeting USP specifications used as solvent/vehicle in gummies and liquids

How to Take It

Take it anytime

Water-soluble — timing is flexible. Consistency matters more than the clock.

With or without food

On the label

Shake well. As a dietary supplement, pump one spray per day into mouth and swallow, or as directed by a health professional.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$17.95

$10$20$50

Near the median of 160 vitamin B9 supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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