BioStacks
Best for
Ingredients (1)
SAMe
100%Dose/day
800 mg
Target
800–1600 mg
Form
Premium
Other Ingredients (7)
ShellacCoating
Natural resin secreted by the lac bug, used as a coating and glazing agent for tablets and pills
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
GlycerinHumectant
Sweet-tasting liquid used in soft capsules and liquids
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Alginic AcidThickener
A seaweed-derived polysaccharide used as a thickener and disintegrant
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
Label directs 2 servings — keep one for the morning
On the label
Take 1 tablet 2 to 3 times daily, preferably on an empty stomach.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$27.92
Cheaper than 70% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.