At 2,000 mcg per capsule, this B12 sits comfortably in the range supplements use to overcome B12's notoriously poor absorption — a genuinely effective dose for energy and the everyday demands of nerve and red blood cell function. It pairs two ready-to-use forms: **adenosylcobalamin**, the form your body stores in mitochondria for cellular energy, and **hydroxocobalamin**, a well-retained form it converts as needed. Both skip the extra methylation step, so you're getting B12 your body can put to work directly.
B12 supplementation matters most if you're vegan or vegetarian, over 50 (absorption naturally declines with age), or taking metformin or acid-reducing medication — all of which lower your B12 status. The label's 1-to-3-capsules-daily range lets you scale up if you're correcting a shortfall rather than just maintaining. At any dose here you're well covered, since B12 is water-soluble and your body simply clears what it doesn't use.
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Ingredients (1)
Vitamin B12
100%Dose
2000 mcg
Target
250–5000 mcg
Form
Premium
Other Ingredients (2)
Hypoallergenic Plant FiberFiller
Plant-derived cellulose fiber used as a hypoallergenic filler, common in Thorne and Pure Encapsulations products
Capsule ShellCapsule
Generic capsule shell where the label does not specify the material. Common materials are hypromellose (HPMC) for vegetarian capsules and gelatin for traditional capsules — both are GRAS-listed and safe. Fish gelatin and pullulan variants also exist.
How to Take It
Best taken in the morning
Many people prefer it earlier in the day; there's no evidence timing changes anything. Absorption is fine with or without food.
With or without food
On the label
As a dietary supplement, take 1 capsule, 1-3 times daily, with meals.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$28.80
Pricier than 90% of 235 vitamin B12 supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.