This pairs a full 800mcg of active **folate** as methylfolate (listed as 1,333mcg DFE) with 800mcg of active **B12** as methylcobalamin — both in the ready-to-use forms that skip the MTHFR conversion step the roughly 40–50% of people with that gene variant handle poorly. At those doses you're comfortably within the ranges that support energy and healthy red-blood-cell formation.

Combining these two is the responsible call rather than dosing either one alone. Folate and B12 work side by side in methylation and blood-cell production, so a shortfall in one limits what the other can do. It also closes a real safety gap: high-dose folate on its own can mask the blood signs of a B12 deficiency and let nerve damage progress unnoticed, which the 800 mcg of B12 here prevents.

At one capsule you're already at a full dose, with room to take two daily if you're correcting a documented deficiency or working down elevated homocysteine. The folate sits right at the top of its typical 400-800 mcg range, and the B12 runs far above the 2.4 mcg daily requirement — generous on purpose, since B12 absorbs poorly and benefits from a wide margin. This is a targeted top-up for people with a genuine methylation need or low B-vitamin status, not an everyday baseline.