This is folate dosed for everyday maintenance: 400 mcg of **L-methylfolate** (Metafolin), exactly the daily requirement and the amount recommended for women of childbearing age to lower the risk of neural-tube defects before and during early pregnancy. You're getting the active form your body uses directly, so it works even if you're among the 40-50% of people whose MTHFR gene variant blocks efficient conversion of synthetic folic acid.

The label's 667 mcg DFE is just the regulatory way of expressing 400 mcg of methylfolate, since the active form counts as roughly 1.7x. That puts you right at the clinical floor for folate status and preconception coverage.

This is a maintenance dose, not a therapeutic one. If you're correcting diagnosed low folate or following a protocol that calls for more, you'd reach for a 1,000 mcg-plus product; for routine daily intake, 400 mcg is the target.