This is a high-dose folate supplement built around methylation and energy support, delivering 5,000mcg of active **L-methylfolate** (8,333mcg DFE on the label) — the form your body uses directly, skipping the conversion step that genetic MTHFR variants can bottleneck. That's a practitioner-tier amount, more than ten times the 400mcg maintenance dose, so if you're working on elevated homocysteine, a known MTHFR variation, or correcting a documented deficiency, you're well into therapeutic territory.

Alongside the folate, you're getting 1,000mcg of **B12** as methylcobalamin and 25mg of **B6** as P5P — both already in the active forms your body can use without conversion. Together these three are the methylation trio that helps keep homocysteine in check and supports steady energy, and at 1,000mcg the B12 comfortably covers the body's low absorption of it.

The B12 here isn't just a bonus, it's the responsible part of the design: high-dose folate on its own can hide the blood signs of a B12 deficiency while nerve problems quietly progress, so pairing it with a real 1,000mcg of B12 is the right way to deliver folate at this level. Just know this is a targeted tool for a specific methylation or homocysteine need — if you only want basic daily folate, it's far more than you require.