BioStacks
Best Passionflower for Stress & Mood
Top 2 products ranked
Last reviewed May 2026
Clinical dose: 250–500 mg
Why Passionflower for Stress & Mood
Passionflower plays a supporting role in stress & mood. Passionflower may improve subjective sleep quality primarily through anxiolytic mechanisms involving GABA-A receptor modulation. Limited RCTs exist, mostly small and focused on anxiety rather than sleep directly.
What dose to look for
Clinical studies typically use 250–500 mg of passionflower. Extract form; limited clinical data available. Products below this range may not deliver meaningful results.
What the research says
Passionflower has limited clinical evidence for stress & mood benefits. Very limited clinical trials, mostly small and focused on anxiety rather than sleep directly Learn more
Clinical research on Passionflower (Passiflora incarnata)
LOW-MODERATE — Comparable to oxazepam, limited RCTs · 200–1,600 mg/day
- •2020 review of 9 RCTs: majority reported reduced anxiety with no adverse effects.
- •GAD trial (36 patients): as effective as oxazepam 30 mg/day with less cognitive impairment.
- •2024 RCT (65 participants, 30 days): reduced PSS and improved quality of life and insomnia scores.
- •Successfully used in benzodiazepine tapering at 200–600 mg/day (approved in Italy as Tractana). Key limitation: mostly 1–30 day durations with small samples.
