BioStacksBest St. John's Wort for Stress & Mood
Top 1 products ranked
Clinical dose: 600–1200 mg
Why St. John's Wort for Stress & Mood
For stress & mood support, St. John's Wort is a key ingredient backed by research. St. John's Wort (Hypericum perforatum) is the most clinically validated herbal antidepressant.
How much st. john's wort do you need
Research points to 600–1200 mg as the effective range for st. john's wort. 600–1,200 mg/day standardized extract (0.3% hypericin or 2–5% hyperforin). WS 5570 and LI 160 are the most studied extracts. Cochrane review (29 RCTs, 5,489 patients) confirms efficacy comparable to SSRIs. Lower doses may provide some benefit, but most studies showing clear results used this range.
The evidence behind st. john's wort
Research supporting st. john's wort for stress & mood is rated as strong. Cochrane review of 29 trials (5,489 patients) confirms efficacy comparable to SSRIs for depression Learn more
