BioStacks
AOR Advanced Orthomolecular Research

Ortho Sleep

2 Capsules · 30 servings · $1.47/serving

iHerbAmazon

Best for

SleepStress & Mood

Ingredients (7)

Melatonin

100%

Dose

3 mg

Target

0.5–5 mg

Form

—

L-Theanine

100%

Dose

200 mg

Target

100–250 mg

Form

—

Lemon Balm (Melissa officinalis L.) aerial parts extract

100%

Dose

300 mg

Target

300–600 mg

Form

—

L-5-Hydroxytryptophan

100%

Dose

100 mg

Target

100–300 mg

Form

—

GABA

100%

Dose

100 mg

Target

100–300 mg

Form

—

Other Ingredients (5)

MaltodextrinBinder

Spikes blood sugar faster than table sugar (glycemic index 85–105). Research links it to gut bacteria changes that may promote intestinal inflammation (Nickerson et al. 2015). Used as a cheap filler — adds nothing beneficial.

Silicon DioxideAnti-caking

Fine silica powder used to prevent clumping

Capsule ShellCapsule

Generic capsule shell where the label does not specify the material. Common materials are hypromellose (HPMC) for vegetarian capsules and gelatin for traditional capsules — both are GRAS-listed and safe. Fish gelatin and pullulan variants also exist.

Gum AcaciaBinder

Natural plant gum (acacia) used as a binder, stabilizer, and emulsifier in foods and supplements

Sodium Stearyl FumarateLubricant

A standard tablet/capsule lubricant, often used in place of magnesium stearate.

How to Take It

Best taken in the evening

Take 30–60 minutes before bed. It's a circadian signal, not a daytime supplement. Take it between meals, away from food.

On an empty stomach
Keep it away from protein-heavy meals
Space it a couple of hours from SAMe

On the label

Take 2 capsules before bedtime with/without food or as directed by a qualified health care practitioner.

Do not combine with St. John's Wort

Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$43.96

$10$20$50

Pricier than 84% of 122 theanine supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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