BioStacks
Best for
Ingredients (1)
SAM-e
50%Dose
400 mg
Target
800–1600 mg
Form
Not listed
Other Ingredients (11)
Titanium DioxideColorant
Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.
Propylene GlycolSolvent
Liquid used to dissolve and preserve supplement ingredients
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Croscarmellose SodiumDisintegrant
Cross-linked cellulose derivative used as a superdisintegrant
Dicalcium PhosphateBinder
Calcium and phosphorus compound used as binder
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
For adults, take two (2) enteric coated tablets daily, preferably on an empty stomach.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$11.99
Cheaper than 99% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.