BioStacks
Designs for Health

5-HTP Supreme™

1 Capsule · 60 servings · $0.86/serving

iHerbAmazon

Best for

Stress & Mood

Ingredients (2)

Vitamin B-6

100%

Dose

20 mg

Target

1.3–25 mg

Form

Premium

5-HTP

100%

Dose

100 mg

Target

100–300 mg

Form

—

Other Ingredients (3)

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

LeucineFlow Aid

Branched-chain amino acid used as a processing aid

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

How to Take It

Best taken in the evening

Contains 5-HTP, so it belongs in the evening. Vitamin B6 is easier on the stomach taken with food.

With food

5-HTP does better on an empty stomach, but something else in this bottle needs food. Taking the whole product with a meal is the better trade — an upset stomach is why most people stop.

Keep it away from protein-heavy meals
Space it a couple of hours from SAMe

On the label

Take 1 capsule per day or as directed by your health-care practitioner.

Do not combine with St. John's Wort

Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$51.49

$10$20$50

Pricier than 90% of 194 vitamin B6 supplements

Track this supplement in your stack

Get personalized insights, interactions, and coverage recommendations.

Get Started Free

Similar Supplements

5-HTP Synergy™

Designs for Health

5-HTP Synergy™

😴 for Sleep

78
5-HTP 50 mg

DaVinci Laboratories

5-HTP 50 mg

😴 for Sleep

71
5-HTP

Thorne

5-HTP

😴 for Sleep

70
5-HTP 200 mg

NutraBio

5-HTP 200 mg

🧘 for Stress & Mood

69
5-HTP Plus+ 200 mg

NatureWise

5-HTP Plus+ 200 mg

😴 for Sleep

55

Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

BioStacks

Know exactly what's in your supplements.

Navigate

  • Home
  • App Store
  • Google Play

Resources

  • Contact & Support
  • Pricing
  • Terms of Service
  • Privacy Policy
  • Refund Policy

Explore

  • Health Areas
  • Best Supplements
  • Nutrients
  • All Supplements

Popular Picks

  • Best Magnesium for Sleep
  • Best Collagen for Skin
  • Best Creatine for Muscle
  • Best Vitamin D for Bone Health
  • Best Probiotics for Digestion
  • Best CoQ10 for Heart
© 2026 BioStacks. All rights reserved. Not medical advice.