BioStacks
NatureWise

5-HTP Plus+ 200 mg

1 Capsule · 60 servings · $0.33/serving

iHerbAmazon

Best for

Sleep

Ingredients (2)

Vitamin B6

100%

Dose

5 mg

Target

1.3–25 mg

Form

Premium

5-HTP

100%

Dose

200 mg

Target

100–300 mg

Form

—

Other Ingredients (4)

Rice ExtractFiller

Rice-based ingredients carry risk of inorganic arsenic contamination. Vague labeling — 'rice extract' does not specify what is extracted or standardized. Used as a cheap filler with no supplemental benefit.

Rice FlourFiller

Rice-based ingredients carry risk of inorganic arsenic contamination (FDA and Consumer Reports). Rice accumulates arsenic from soil at higher rates than other grains. Used as a cheap filler — adds nothing beneficial.

Gellan GumGelling Agent

Microbial polysaccharide produced by Sphingomonas elodea, used as a gelling and stabilizing agent

HypromelloseCapsule

Plant-derived capsule material from cellulose

How to Take It

Best taken in the evening

Contains 5-HTP, so it belongs in the evening. Vitamin B6 is easier on the stomach taken with food.

With food

5-HTP does better on an empty stomach, but something else in this bottle needs food. Taking the whole product with a meal is the better trade — an upset stomach is why most people stop.

Keep it away from protein-heavy meals
Space it a couple of hours from SAMe

On the label

Adults take 1 capsule daily with food or as recommended by your healthcare provider.

Do not combine with St. John's Wort

Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.

General guidance based on the ingredients, not a substitute for the label or your doctor.

Price Check

$19.99

$10$20$50

Near the median of 187 vitamin B6 supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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