BioStacks
Ingredients (4)
Vitamin B12
20%Dose
50 mcg
Target
250–5000 mcg
Form
Premium
Vitamin B-6
20%Dose
5 mg
Target
25–100 mg
Form
Premium
Folate
43%Dose
170 mcg DFE
Target
400–800 mcg
Form
Premium
SAMe
25%Dose
200 mg
Target
800–1600 mg
Form
Standard
Other Ingredients (3)
Vegetable StearateLubricant
A plant-derived salt of stearic acid (typically magnesium or calcium) used as a tablet lubricant
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
How to Take It
Best taken in the morning
Contains SAMe, which is stimulating — keep it to the morning. Vitamin B6 is easier on the stomach taken with food.
With food
SAMe does better on an empty stomach, but something else in this bottle needs food. Taking the whole product with a meal is the better trade — an upset stomach is why most people stop.
Space it a couple of hours from 5-HTP
On the label
Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$124.99
Pricier than 95% of 22 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.