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What it does
A combination of 6 label ingredients.
5-HTP
Form not confirmedGrade —
Studied for low mood, but reliable evidence of benefit remains insufficient.
Vitamin B6
Mixed formsGrade —
Supports normal protein metabolism, neurotransmitter production and hemoglobin formation.
Ingredients (8)
Other ingredients
Rice FlourFiller
Rice-based ingredients carry risk of inorganic arsenic contamination (FDA and Consumer Reports). Rice accumulates arsenic from soil at higher rates than other grains. Used as a cheap filler — adds nothing beneficial.
BiotinFood
Vitamin B7, a water-soluble B-vitamin.
Folic AcidVitamin
Synthetic form of vitamin B9 used for fortification — supports red blood cell formation and neural tube development. Pharmacologically distinct from the natural/active form (5-methyltetrahydrofolate, methylfolate).
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
HypromelloseCapsule
Plant-derived capsule material from cellulose
NicotinamideVitamin
Amide form of vitamin B3 used for fortification; supports cellular energy and NAD+ synthesis without flushing
L-5-Hydroxytryptophan
Not reviewed yet
Lab testing
How to take it
With food
5-HTP does better on an empty stomach, but something else in this bottle needs food. Taking the whole product with a meal is the better trade — an upset stomach is why most people stop.
Keep it away from protein-heavy meals
Space it a couple of hours from Iron, Calcium and SAMe
On the label
Adults take 1-2 capsules a day preferably before bed with a carbohydrate snack, or as your health professional advises.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
Price check
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What 61 5-HTP supplements cost
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.
Not medical advice. Consult your healthcare professional.