This two-ingredient capsule delivers folate and B12 in their already-active forms at doses that hit clinical ranges for energy, methylation, and healthy red blood cell production. You're getting **folate** as L-methylfolate at 680 mcg DFE — about 400 mcg of actual methylfolate, since methylfolate counts as roughly 1.7x its weight in DFE — in the form your body can use directly, with none of the conversion step that synthetic folic acid requires. That matters for the 40–50% of people carrying MTHFR gene variants, who convert standard folic acid poorly: here you skip that bottleneck entirely and get folate your cells can actually put to work.

**Vitamin B12** comes as methylcobalamin at 300 mcg, again an active form you use straight away, sitting comfortably within the 250–5,000 mcg range supplements use to overcome low absorption. Pairing the two is the responsible design rather than a marketing flourish: folate and B12 work side by side in methylation and red blood cell formation, and taking high-dose folate on its own can mask a developing B12 deficiency. Delivering both together closes that gap.

This is a strong fit if you're vegan, over 50, planning a pregnancy, or know you carry an MTHFR variant — all groups where one or both of these nutrients run low or convert poorly. At one capsule daily with both in ready-to-use form, you reach an effective intake without guesswork.

BioStacks
Life Extension

BioActive Folate & Vitamin B12

1 Capsule · 150 servings · $0.11/serving

iHerbAmazon

Best for

Energy

Ingredients (2)

Folate

100%

Dose

680 mcg DFE

Target

400–800 mcg

Form

Premium

Vitamin B12

100%

Dose

300 mcg

Target

250–5000 mcg

Form

Premium

Other Ingredients (3)

Dicalcium PhosphateBinder

Calcium and phosphorus compound used as binder

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Microcrystalline CelluloseBinder

Plant-derived cellulose used as a binder and filler in supplements

Track this supplement in your stack

Get personalized insights, interactions, and coverage recommendations.

Get Started Free

Similar Supplements

Products that cover similar health dimensions based on their ingredients.

Methyl Combo

Nature's Sunshine

Methyl Combo

🤰 for Pregnancy

99
5-MTHF / B12 MC 2000

DaVinci Laboratories

5-MTHF / B12 MC 2000

🤰 for Pregnancy

99
L-Methylfolate 5-MTHF + B12

NatureWise

L-Methylfolate 5-MTHF + B12

🤰 for Pregnancy

98
B12 Folate

Pure Encapsulations

B12 Folate

🤰 for Pregnancy

98
L-Methylfolate 5-MTHF Capsules

Triquetra Health

L-Methylfolate 5-MTHF Capsules

🤰 for Pregnancy

98

Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

BioStacks

Know exactly what's in your supplements.

Navigate

  • Home
  • App Store
  • Google Play

Resources

  • Contact & Support
  • Terms of Service
  • Privacy Policy

Explore

  • Health Areas
  • Best Supplements
  • Nutrients
  • All Supplements

Popular Picks

  • Best Magnesium for Sleep
  • Best Collagen for Skin
  • Best Creatine for Muscle
  • Best Vitamin D for Bone Health
  • Best Probiotics for Digestion
  • Best CoQ10 for Heart
© 2026 BioStacks. All rights reserved. Not medical advice.