BioStacks
Best for
Ingredients (3)
Folate
100%Dose
1665 mcg dfe
Target
400–800 mcg
Form
Premium
Vitamin B12
100%Dose
1000 mcg
Target
250–5000 mcg
Form
Premium
S-Adenosyl-L-Methionine
50%Dose
400 mg
Target
800–1600 mg
Form
Not listed
Other Ingredients (7)
MannitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at higher doses. Supplement amounts are typically small, but individuals with IBS or sugar alcohol sensitivity may react even at low doses.
Coating (unspecified)Coating
Generic tablet coating declaration where the label does not itemize the coating's components; modern aqueous film coatings are typically cellulose-based (HPMC) with a plasticizer
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
StarchBinder
Carbohydrate polymer used as a binder, filler, and disintegrant in tablets and capsules
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
Directions: Take one tablet daily 30 minutes before a meal on an empty stomach with water or as directed by your healthcare practitioner.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$78.93
Pricier than 84% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.