BioStacks
Every active here is dosed below the amount studied to work. See how each one compares in the breakdown below.
Best for
Ingredients (1)
SAMe
25%Dose
200 mg
Target
800–1600 mg
Form
Premium
Other Ingredients (7)
MannitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at higher doses. Supplement amounts are typically small, but individuals with IBS or sugar alcohol sensitivity may react even at low doses.
Coating (unspecified)Coating
Generic tablet coating declaration where the label does not itemize the coating's components; modern aqueous film coatings are typically cellulose-based (HPMC) with a plasticizer
Magnesium StearateLubricant
A salt of stearic acid used as a lubricant in tablet and capsule production
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Glyceryl BehenateLubricant
Glyceryl ester of behenic acid used as a tablet lubricant and controlled-release matrix agent
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
StarchBinder
Carbohydrate polymer used as a binder, filler, and disintegrant in tablets and capsules
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
1 tablet on an empty stomach, 2 times per day for 3 weeks; then 1 tablet per day thereafter, or as directed by a health professional.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$18.87
Cheaper than 90% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.