Pure Encapsulations O.N.E. is a once-daily foundational multivitamin that hits genuinely useful daily doses across its core vitamins and minerals, using bioactive forms your body can absorb directly. The B vitamins come pre-activated — including **folate** as methylfolate and **Vitamin B12** as methylcobalamin — so your body doesn't have to convert them first, which helps if you carry the common gene variant that slows folate activation. Paired with **Vitamin D3** at 2,000 IU and natural vitamin E, you get real daily coverage from a single capsule.

On the mineral side you're solidly covered for everyday needs. **Zinc** sits at 25mg and **selenium** comes as well-absorbed selenomethionine, a pairing that supports immune function and thyroid health, alongside a full 150mcg of iodine and 200mcg of chromium. These are the doses that actually move the needle for the energy, immune, and general daily-health goals a foundational multi should deliver on.

Set your expectations on the extras, though. The formula also features CoQ10, alpha-lipoic acid, lutein, and zeaxanthin, but each sits well below its studied dose — CoQ10 at 50mg against the 100–300mg used in research, lutein at 3mg versus the 10mg in the main eye-health trial, and alpha-lipoic acid at 50mg against a 300–600mg clinical range. They add antioxidant variety, but if you're buying this specifically for eye support or CoQ10, you're getting a fraction of an effective dose.

One practical note: there's no iron here, which suits men and post-menopausal women who don't want the extra — but if you're correcting low iron, you'll need a separate source.