BioStacks
Best for
Ingredients (3)
Folate
100%Dose
667 mcg DFE
Target
400–800 mcg
Form
Premium
Vitamin B12
100%Dose
1000 mcg
Target
250–5000 mcg
Form
Premium
L-5-MTHF
100%Dose
400 mcg
Target
400–800 mcg
Form
Premium
Other Ingredients (6)
CarboxymethylcelluloseThickener
Carboxymethylcellulose was the second emulsifier (with polysorbate 80) in Chassaing et al. 2015 (Nature, PMID 25731162), which showed mucus-barrier thinning, a microbiota shift toward pro-inflammatory species, low-grade inflammation, and metabolic syndrome in mice. Chassaing 2022 (Gastroenterology, PMID 34774538) tested CMC directly in a randomized controlled human feeding trial and found reduced microbial diversity and bacterial encroachment into the normally sterile mucus layer in a susceptible subset of participants. EFSA's 2018 re-evaluation could not establish a safe level due to data gaps. For a purely textural excipient, the gut-barrier risk profile is unfavorable when safer thickeners are widely available.
MannitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at higher doses. Supplement amounts are typically small, but individuals with IBS or sugar alcohol sensitivity may react even at low doses.
XylitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at moderate doses (>10-20g/day), though supplement amounts are typically small. Extremely toxic to dogs — households with pets should store securely.
Natural Black Cherry FlavorFlavor
A proprietary natural flavoring blend imparting black-cherry taste
Natural FlavorsFlavor
Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.
Ascorbyl PalmitateAntioxidant
Fat-soluble form of vitamin C used as preservative
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.