BioStacks
Pure Encapsulations

SAMe (S-Adenosylmethionine)

1 Capsule · 60 servings · $1.41/serving

iHerbAmazon

Every active here is dosed below the amount studied to work. See how each one compares in the breakdown below.

Best for

Stress & Mood

Ingredients (1)

SAMe

25%

Dose

200 mg

Target

800–1600 mg

Form

Premium

Other Ingredients (5)

Ascorbyl PalmitateAntioxidant

Fat-soluble form of vitamin C used as preservative

Calcium CarbonateBuffer

Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements

Calcium CarbonateBuffer

Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements

Hypoallergenic Plant FiberFiller

Plant-derived cellulose fiber used as a hypoallergenic filler, common in Thorne and Pure Encapsulations products

Capsule ShellCapsule

Generic capsule shell where the label does not specify the material. Common materials are hypromellose (HPMC) for vegetarian capsules and gelatin for traditional capsules — both are GRAS-listed and safe. Fish gelatin and pullulan variants also exist.

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Similar Supplements

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Sources & Scoring

Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).

This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.

The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.

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