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What it does
SAMe
Form not confirmedGrade —
Studied for depression and joint pain; evidence for oral supplementation remains inconclusive and it can interact with medicines.
Ingredients (1)
Other ingredients
Titanium DioxideColorant
Banned in the EU (2022) over concerns that its ultra-fine particles may damage DNA in gut cells. Still allowed in the US. Used only for white coloring — provides no health benefit.
MannitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at higher doses. Supplement amounts are typically small, but individuals with IBS or sugar alcohol sensitivity may react even at low doses.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Yellow OchreColorant
Natural iron-oxide mineral pigment used to color tablet coatings and capsule shells a yellow-tan hue
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Citric AcidAcidulant
Natural acid derived from citrus fruits
Croscarmellose SodiumDisintegrant
Cross-linked cellulose derivative used as a superdisintegrant
Microcrystalline CelluloseBinder
Plant-derived cellulose used as a binder and filler in supplements
Lab testing
How to take it
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
2 tablets, 1 to 3 times daily. Take tablets on an empty stomach.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
Price check
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What 24 SAMe supplements cost
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.
Not medical advice. Consult your healthcare professional.