Each tablet of this **SAMe** supplement carries 200mg of active S-adenosylmethionine for mood and stress support, a low per-tablet dose given that the antidepressant research, including a 2024 meta-analysis of 23 trials, used 800 to 1,600mg a day. To reach that studied range you'd need roughly 4 to 8 tablets daily, which is why the label directs 2 tablets one to four times per day. A single 2-tablet serving lands at 400mg, half the effective floor.
The active comes as a stable tosylate disulfate in an enteric coating, which protects fragile SAMe through the stomach. Take it on an empty stomach for the best absorption.
One caution worth knowing: SAMe can trigger mania if you have bipolar disorder, and combined with SSRIs or other antidepressants it raises the risk of serotonin syndrome, so check with a doctor before pairing it with those medications.
BioStacks
Best for
Ingredients (1)
SAMe
50%Dose
400 mg
Target
800–1600 mg
Form
Premium
Other Ingredients (12)
Propylene GlycolSolvent
Liquid used to dissolve and preserve supplement ingredients
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Ascorbic AcidAntioxidant
Vitamin C used as an antioxidant preservative in supplements to prevent oxidation
Ascorbyl PalmitateAntioxidant
Fat-soluble form of vitamin C used as preservative
Calcium CarbonateBuffer
Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements
Citric AcidAcidulant
Natural acid derived from citrus fruits
Croscarmellose SodiumDisintegrant
Cross-linked cellulose derivative used as a superdisintegrant
Hydroxypropyl CelluloseBinder
An inert modified-cellulose polymer used as a binder, film-former, and disintegrant.
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.