Each tablet of this **SAMe** supplement carries 200mg of active S-adenosylmethionine for mood and stress support, a low per-tablet dose given that the antidepressant research, including a 2024 meta-analysis of 23 trials, used 800 to 1,600mg a day. To reach that studied range you'd need roughly 4 to 8 tablets daily, which is why the label directs 2 tablets one to four times per day. A single 2-tablet serving lands at 400mg, half the effective floor.
The active comes as a stable tosylate disulfate in an enteric coating, which protects fragile SAMe through the stomach. Take it on an empty stomach for the best absorption.
One caution worth knowing: SAMe can trigger mania if you have bipolar disorder, and combined with SSRIs or other antidepressants it raises the risk of serotonin syndrome, so check with a doctor before pairing it with those medications.
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Ingredients (1)
SAMe
50%Dose
400 mg
Target
800–1600 mg
Form
Premium
Other Ingredients (12)
Propylene GlycolSolvent
Liquid used to dissolve and preserve supplement ingredients
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Ascorbic AcidAntioxidant
Vitamin C used as an antioxidant preservative in supplements to prevent oxidation
Ascorbyl PalmitateAntioxidant
Fat-soluble form of vitamin C used as preservative
Calcium CarbonateBuffer
Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements
Citric AcidAcidulant
Natural acid derived from citrus fruits
Croscarmellose SodiumDisintegrant
Cross-linked cellulose derivative used as a superdisintegrant
Hydroxypropyl CelluloseBinder
An inert modified-cellulose polymer used as a binder, film-former, and disintegrant.
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
As a dietary supplement, take two tablets one to four times per day with water.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$25.19
Cheaper than 78% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from the NIH Office of Dietary Supplements and the National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.