This **SAMe** tablet delivers 400mg of active S-adenosylmethionine, the best-studied natural compound for low mood, where trials have found it comparable to prescription antidepressants. That 400mg sits at the floor of the 400–1,600mg studied range — a real, usable dose, though most mood and joint-pain trials run higher.

The label's one-to-four-tablets-a-day window lets you climb to 800–1,600mg, where the strongest evidence for both depression and osteoarthritis sits; two tablets daily is a sensible target. The enteric-coated tosylate form matters, since SAMe is chemically fragile — take it on an empty stomach for best absorption.

One real caveat: SAMe can trigger mania in people with bipolar disorder, and combined with SSRIs or other antidepressants it raises serotonin-syndrome risk. If you take any mood medication, talk to your doctor first.