BioStacks
Other Ingredients (7)
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Calcium CarbonateBuffer
Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements
Purified WaterSolvent
Water meeting USP specifications used as solvent/vehicle in gummies and liquids
Ascorbyl PalmitateAntioxidant
Fat-soluble form of vitamin C used as preservative
Calcium CarbonateBuffer
Common calcium salt used as a buffering agent, filler, or mineral fortification in supplements
Gellan GumGelling Agent
Microbial polysaccharide produced by Sphingomonas elodea, used as a gelling and stabilizing agent
HypromelloseCapsule
Plant-derived capsule material from cellulose
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
Take one capsule daily, or as directed by your healthcare practitioner.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$72.00
Pricier than 70% of 24 SAMe supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. studied ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.