BioStacks
Every active here is dosed below the amount studied to work. See how each one compares in the breakdown below.
Best for
Ingredients (3)
S-Adenosyl-L-Methionine
50%Dose
400 mg
Target
800–1600 mg
Form
Not listed
Betaine Anhydrous
24%Dose
600 mg
Target
2500–6000 mg
Form
—
Calcium
75 mgTrace amount — not scored
Other Ingredients (7)
XylitolSweetener
A FODMAP sugar alcohol that can cause GI distress (bloating, gas, diarrhea) at moderate doses (>10-20g/day), though supplement amounts are typically small. Extremely toxic to dogs — households with pets should store securely.
Turmeric ColorColorant
Natural yellow colorant from the rhizome of Curcuma longa; the pigment is curcumin
Natural FlavorsFlavor
Broad regulatory category of flavor constituents derived from natural sources. Composition is proprietary and not disclosed — 'Natural Flavors' can include several hundred different compounds depending on the target flavor profile, including hexane-extracted constituents and proprietary carrier solvents. 'Natural' is a regulatory definition (21 CFR §101.22), not a safety guarantee.
Silicon DioxideAnti-caking
Fine silica powder used to prevent clumping
Citric AcidAcidulant
Natural acid derived from citrus fruits
Malic AcidAcidulant
Naturally occurring organic acid found in apples, used as a flavor enhancer and acidulant in supplements
Stearic AcidLubricant
Saturated fatty acid used as tablet lubricant
How to Take It
Best taken in the morning
Take in the morning on an empty stomach — it can be activating and may disturb sleep later in the day.
On an empty stomach
Space it a couple of hours from 5-HTP
On the label
Consume the contents of one stick pack daily away from meals, or as directed by your healthcare practitioner. Preferably pour a small amount of the contents of a stick pack directly into the mouth and allow contents to dissolve. Then repeat process until contents of the entire stick pack have dissolved in the mouth. Alternatively, contents may be added to 2-4 oz of water or preferred liquid; stir and drink within 15 minutes.
Do not combine with St. John's Wort
Each of these raises serotonin activity on top of St. John's Wort, and together they can trigger serotonin syndrome — agitation, rapid heartbeat, raised blood pressure. Not without medical supervision.
General guidance based on the ingredients, not a substitute for the label or your doctor.
Price Check
$101.00
Pricier than 99% of 34 TMG (Trimethylglycine) supplements
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Sources & Scoring
Nutrient data (RDA, UL, and safety thresholds) sourced from: NIH Office of Dietary Supplements and National Academies Dietary Reference Intakes (DRI).
This is not medical advice. Consult a healthcare provider before making changes to your supplement routine.
The score analyzes what's on the label: ingredient doses vs. clinical ranges, chemical forms, evidence levels, and known interactions. It does not verify label accuracy or test for contaminants — for that, look for third-party certifications like USP or NSF.