BioStacksBest Vitamin B9 for Liver
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Clinical dose: 400–800 mcg
Why Vitamin B9 for Liver
Vitamin B9 is a supporting nutrient for liver support. Critical for DNA synthesis, cell division, and methylation reactions. 5-MTHF (methylfolate) is the bioactive form that the body can use directly, unlike synthetic folic acid which requires multi-step conversion via the MTHFR enzyme. Around 40–50% of people carry MTHFR gene variants that impair folic acid conversion, making methylfolate the preferred supplemental form.
Effective dosing
Most evidence supports 400–800 mcg of vitamin b9 daily. Products below this range may not deliver meaningful results.
Form and bioavailability
Avoid folic acid — synthetic, ~60% conversion rate. Look for methylfolate (5-mthf) for better absorption.
The evidence behind vitamin b9
Research supporting vitamin b9 for liver is rated as strong. Strong evidence for neural tube defect prevention; 40-50% of people have MTHFR variants affecting conversion Learn more