BioStacks

Best Vitamin B9 for Liver

Top 9 products ranked

Last reviewed May 2026

Clinical dose: 400–800 mcg

Why Vitamin B9 for Liver

Vitamin B9 plays a supporting role in liver. Critical for DNA synthesis, cell division, and methylation reactions. 5-MTHF (methylfolate) is the bioactive form that the body can use directly, unlike synthetic folic acid which requires multi-step conversion via the MTHFR enzyme.

What dose to look for

Clinical studies typically use 400–800 mcg of vitamin b9. Products below this range may not deliver meaningful results.

What form to look for

Avoid folic acid — synthetic, ~60% conversion rate. Look for methylfolate (5-mthf) for better absorption.

What the research says

Vitamin B9 has strong clinical evidence for liver benefits. Strong evidence for neural tube defect prevention; 40-50% of people have MTHFR variants affecting conversion Learn more

Clinical research on Folate (Vitamin B9)

LOW for liver specifically — essential for methylation, limited liver-specific data · 400–800 mcg DFE/day

•Folate is essential for one-carbon metabolism and DNA methylation. Animal studies show folate deficiency exacerbates hepatic steatosis and fibrosis. Methyl-donor depletion diets (low choline + low folate) reliably induce NAFLD in rodents.
•Observational data from NHANES suggests inverse association between folate intake and NAFLD prevalence, but confounding is significant (folate tracks with overall diet quality).
•No RCTs demonstrate that folate supplementation reverses or prevents liver disease in humans with adequate dietary intake. Supplementation is warranted for deficiency correction, not as a liver-specific intervention.

See full Liver research →